Michael Kobor

Dr. Michael S. Kobor is a Professor of Medical Genetics at UBC and Tier 1 Canada Research Chair in Social Epigenetics.  A Senior Scientist at the Centre for Molecular Medicine and Therapeutics (CMMT), Dr. Kobor serves as Theme Lead for Healthy Starts at BC Children’s Hospital. Dr. Kobor is an Investigator with the Kids Brain Health Network NCE, a co-lead of the Gene X Environment Platform of the AllerGen NCE, and a Senior Fellow in the Child and Brain Development Program of the Canadian Institute for Advanced Research (CIFAR).

Dr. Kobor completed his PhD in Medical Genetics under Dr. Jack Greenblatt at the University of Toronto before undertaking postdoctoral training as a Human Frontier Science Program Fellow with Dr. Jasper Rine at the University of California, Berkeley. 

Research in Dr. Kobor’s laboratory is focused on the epigenetic regulation of gene expression and genome function. Particular emphasis is placed on understanding the mechanistic nature of these processes and their modulation by environmental exposures. Dr. Kobor’s research team utilizes an interdisciplinary approach, with investigations spanning the entire spectrum from model organisms to human populations.  Through a variety of research approaches, ongoing work in Dr. Kobor’s laboratory touches on some of the fundamental questions in chromatin biology.  These queries include how distinct chromosomal neighbourhoods are established, how they function and interact with enzymes involved in DNA metabolism, what the functional differences between histone variants and canonical histones are, and how chromatin-remodeling complexes are regulated.  Most recently, working with his research team and interdisciplinary collaborators, Dr. Kobor has begun investigating epigenetic variation in humans, with a particular focus on the effects of social environment on lifelong health and aging.  These studies aim to decipher the mechanisms by which environmental exposures and life experiences can “get under the skin” to regulate the activity of genes and contribute to human physiology and behaviour during the life course of an individual. 

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